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[Preprint]. 2023 Jul 11:2023.07.11.548558. [Version 1] doi: 10.1101/2023.07.11.548558

Figure 2: Aβ aggregated species accumulate in the myocardial parenchyma in association with cardiac cell apoptosis.

Figure 2:

(A-B): Plots show Aβ40 (A) Aβ42 (B) levels (pg/mL), assessed by ELISA assay in heart lysates from 12 months old WT and Tg2576 mice. (C-E): Representative immunoblots (left panels) and densitometric analysis (right panels) showing levels of Aβ dimers, oligomers (D) and Cleaved-Caspase3 (Cl-Casp3, E) in total heart lysates of 12-month-old WT and Tg2576 mice. GAPDH levels are used as a loading control. (F-G): Representative digital images (top panels, scale bar 100μm) showing collagen type I fibers (COL1A1, in green) and Aβ aggregates (in red) and, representative digital images (bottom panels; scale bar 100μm) showing Cleaved-Caspase3 (Cl-Casp3, in green) and Aβ aggregates (in red) in cardiac sections from WT (left panels) and Tg2576 (right panels) mice. n=3– 5 mice/group. Data are presented as a mean±SEM. *P<0.05, **P<0.01, ***P<0.001 and vs WT. Student t-tests have been performed between the 2 groups.