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[Preprint]. 2025 Jun 4:2023.07.11.548558. Originally published 2023 Jul 11. [Version 3] doi: 10.1101/2023.07.11.548558

Figure 4. Aβ40 oligomers induce BDNF downregulation in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs).

Figure 4.

(A) Representative immunoblots (upper panels) and densitometric quantitative analysis (lower panel) showing protein levels of BDNF in total protein lysates from hiPSC-CMs stimulated with human Aβ40 oligomers for 20h. ACTIN levels were used as loading control. (B) Representative digital images (scale bar 10μm) of hiPSC-CMs stained with BDNF (red), cardiac Troponin T (cTnT, in green), and DAPI (blue). n=3. Data are presented as a mean±SEM. *P<0.05 and vs NT. Student t-tests have been performed between the groups. (NT= Not Treated).