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[Preprint]. 2025 Jun 4:2023.07.11.548558. Originally published 2023 Jul 11. [Version 3] doi: 10.1101/2023.07.11.548558

Figure 5. Myocardial neuro-signaling impairment and Aβ deposits in human post-mortem cardiac tissue of AD subjects.

Figure 5.

(A-B): Representative immunoblots (A) and densitometric analysis (B) showing reduced levels of BDNF, GAP-43, TH, but not NGF in total human LV lysates of patients with AD+CAA compared to healthy donors (CTRL). GAPDH levels were used as a loading control. (C-D): Representative digital images (C, scale bar 50μm), and quantification (D) of the LV sections from CTRL and AD+CAA subjects stained with Aβ aggregates (in green) and cardiac Troponin I (cTnI, in red). n=4–7 subjects/group. Data are presented as a mean±SEM. *P<0.05 and vs CTRL. Student t-tests have been performed between the groups.