Skip to main content
[Preprint]. 2025 Jun 4:2023.07.11.548558. Originally published 2023 Jul 11. [Version 3] doi: 10.1101/2023.07.11.548558

Figure 2. Alzheimer’s disease pathology negatively impacts the neuro-signaling pathway in the brain/heart axis of Tg2576 mice.

Figure 2.

(A-B): Representative immunoblots (A) and densitometric analysis (B) showing levels of NGF, BDNF, GAP-43, and dβh in total heart tissue and cerebral cortex lysates from WT and Tg2576 mice. GAPDH levels were used as a loading control. (C-E): Digital images (C, scale bar 100μm) and quantifications (D-E) showing cardiac adrenergic nerve fibers, labeled with anti-tyrosine-hydroxylase (TH, in green) (D), and cardiac regenerating nerve endings, labeled with anti-neuronal regeneration marker (GAP-43, in red) (E), in cardiac sections from WT and Tg2576 mice. n=3–5 mice/group. Data are presented as a mean±SEM. *P<0.05 and vs WT. Student t-tests have been performed between the groups.