Figure 5. A. The best ICS model submitted by the community vs. the best ICS model submitted by NBIS-AF2-M.

The color code used for the best community submissions follows the one in Figure 1. The best NBIS-AF2-M models are shown in tan. Each data point is marked with the complex type, where Ho stands for homomer, He for heteromeric, Int for intertwined, Nb for nanobody-antigen, Ab for antibody-antigen, and MI for mutation-induced change. The targets where NBIS-AF2-M and the community produced similar successful models (ΔICS<0.25) are marked with an asterisk *. The tabulated form of this plot is provided as Table 3. B. The best ICS model submitted by the community, the best ICS model submitted by AF2M and the experimental structure for H1111, C. H1114, D. T1179o and E. H1129. The best ICS models were depicted in color and the experimental structures were depicted in gray.