Table 3.

ΔICS values for each target, the best ICS of NBIS-AF2-M, the best ICS and its performed group, which groups performed well and the reason for NBIS-AF2-M failure.

Target ID	NBIS-AF2-M ICS	The best ICS	The best ICS model's group	ΔIC S	Community and NBIS-AF2-M performed well	Nobody performed well	Community performed well	The reason of NBIS-AF2-M failure
H1106	0.80	0.84	OpenFold	0.03	×
H1111	0.04	0.61	Yang-Multimer	0.57			×	technical limitation
H1114	0.17	0.84	Yang	0.67			×	technical limitation
H1114v2	0.38	0.62	Venclovas	0.24			×	technical limitation
H1129	0.08	0.76	Wallner	0.67			×	wrong interface
H1134	0.69	0.81	Wallner	0.12	×
H1135	0.38	0.68	UltraFold	0.30			×	wrong interface
H1137	0.66	0.83	bio3d	0.16	×
H1140	0.10	0.81	Wallner	0.71			×	Nanobody-antigen
H1141	0.09	0.80	Zheng	0.72			×	nanobody-antigen
H1142	0.00	0.45	Kiharalab	0.45		×		nanobody-antigen
H1143	0.92	0.92	NBIS-AF2-multimer	0.00	×
H1144	0.09	0.74	Zheng	0.65			×	nanobody-antigen
H1151	0.82	0.84	Wallner	0.02	×
H1157	0.74	0.79	Manifold-E	0.05	×
H1166V1	0.20	0.30	Manifold-E	0.09		×		antibody-antigen
H1167V1	0.00	0.12	ShanghaiTech	0.12		×		antibody-antigen
H1168V1	0.71	0.84	DFolding-refine	0.13	×
H1171	0.58	0.62	MultiFOLD	0.04	×
H1172	0.56	0.63	Manifold-LC-E	0.07	×
H1185	0.70	0.72	Yang	0.03	×
T1109o	0.52	0.85	Wallner	0.33			×	Mutation induced change
T1110o	0.92	0.95	ColabFold	0.03	×
T1113o	0.79	0.93	Manifold	0.14	×
T1115o	0.18	0.68	Venclovas	0.50			×	technical limitation
T1121o	0.42	0.68	DFolding-server	0.25			×	wrong interface
T1123o	0.20	0.46	MULTICOM_deep	0.27		×		viral protein/weak evolutionary signal
T1124o	0.87	0.89	MULTICOM	0.02	×
T1127o	0.91	0.91	NBIS-AF2-multimer	0.00	×
T1132o	0.86	0.90	BAKER	0.04	×
T1153o	0.74	0.86	MULTICOM_qa	0.12	×
T1160o	0.16	0.57	PEZYFoldings	0.41			×	Mutation induced change
T1161o	0.36	0.92	Wallner	0.56			×	Mutation induced change
T1170o	0.57	0.65	Yang	0.08	×
T1173o	0.47	0.69	Yang	0.22	×
T1174o	0.81	0.90	Manifold-E	0.09	×
T1178o	0.64	0.72	DFolding-server	0.09	×
T1179o	0.16	0.81	DFolding	0.65			×	wrong interface
T1181o	0.49	0.63	PEZYFoldings	0.14	×
T1187o	0.00	0.95	Venclovas	0.95			×	wrong interface
T1192o	0.70	0.75	Yang	0.05	×