Figure 1. Assigning known mutational signatures to an individual sample and individual mutations with SigProfilerAssignment.

SigProfilerAssignment supports input data in a standard format (VCF, MAF, or text) and it allows assigning a set of known signatures (e.g., ones from the COSMIC database) to an a) individual sample and b) probabilistically to an individual somatic mutation. Note that the probabilistic assignment of mutational signatures to an individual somatic mutation is only possible if a user provides a list of individual mutations (e.g., VCF file) for the examined sample instead of a mutational vector, as a mutational vector lacks information for individual mutations.