Figure 2. Benchmarking of SigProfilerAssignment and four other tools for assigning mutational signatures.

Each tool was evaluated using 2,700 synthetic cancer genomes generated using 21 different COSMIC reference mutational signatures. All COSMICv3.3 signatures were used as the input set of known mutational signatures. a) Three different levels of non-systematic random noise (0%, 5%, and 10%) were used to evaluate the precision (x-axes), sensitivity (y-axes), and F₁ scores (harmonic mean of precision and sensitivity; red dotted lines) of each tool. b) Computational benchmarking based on CPU elapsed time (x-axis; log-scaled) and maximum memory usage (y-axis) for each tool.