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[Preprint]. 2023 Jul 13:2023.07.13.548758. [Version 1] doi: 10.1101/2023.07.13.548758

Figure 2. Intravitreal injections of EGFP mRNA transfects retinal cells in the mouse.

Figure 2.

Two amino lipid formulations, 2T and 6T, were compared for their ability to transfect retinal cells at various time points. Confocal images of retinal cross-sections with DAPI and EGFP staining are shown. EGFP is expressed in similar cell populations at (A) 48 hours, (B) 72 hours, (C) 96 hours, (D) 1 week, and (E) 2 weeks for both 2Tand 6T LNPs. Images shown are representative of at least 3 retinas and are MIPs (scale bar: 50 μM).