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[Preprint]. 2023 Jul 12:2023.07.12.548582. [Version 1] doi: 10.1101/2023.07.12.548582

Figure 1: Overview of PTP1B structure and key sites.

Figure 1:

A. Schematic of full-length PTP1B primary structure, including catalytic domain and disordered C-terminus. Key structural sites in the catalytic domain are labeled. The 1–321 construct used throughout this study is indicated below the diagram. The last ~22 residues of this construct do not appear in crystal structures.

B. Superposed structures of the PTP1B catalytic domain bound to the active-site inhibitor TCS401 (green, PDB ID 5K9W, closed state) and bound to the allosteric inhibitor BB3 (purple, PDB ID 1T49, open state).

C. Close-up view of PTP1B active site showing the positions of catalytic loops surrounding TCS401.