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The structure of PTP1B in complex with (A) the active-site inhibitor TCS401 (PDB ID 5K9W) and (B) the allosteric inhibitor BB3 (PDB ID 1T49) color-mapped with the deconvoluted differential HDX values at 30 seconds of labeling time. Particular peptides of interest have been selected and their fractional deuterium build-up plots shown. See also Fig. S3.
