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A. Woods plot of HDX rates for 312 peptides of apo PTP1B showing %deuteration at 30 seconds of labeling for each peptide.
B. Deconvoluted HDX rates at 30 s of labeling time mapped to a crystal structure of the PTP1B catalytic domain in the closed state (PDB ID 1SUG). Several key loops and the α4 helix (residues 187-200) and α7 helix (residues 285-298) are indicated.
