Figure 3. The I40V mutation increased size and density of aggregates induced by flow shear.
Red and blue data indicate I40V and WT apoLECT2, respectively. Sizes of deposits were characterized by their fractional areas (left plots), and densities of deposits by their integrated intensities (center plots) and per-pixel intensities (right plots). Fold changes between I40V and WT, when significant, are indicated by the numbers above the bars. The number of data points (circles) for the 40/20 μm, 80/40 μm, and 160/80 μm junctions were 30, 15, and 10, respectively. ****, p<10−4; ***, p<10−3; **, p<10−2; ns, not significant. See Supporting Figures S5 – S11 for additional BR data.