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[Preprint]. 2023 Jul 15:2023.07.14.549057. [Version 1] doi: 10.1101/2023.07.14.549057

Figure 3. Model of VP35 interacting with Ubiquitin.

Figure 3.

A) The complex of VP35 (PDB ID 3JKE) and Ubiquitin (PDB ID 1UBQ) modelled using a combination of protein docking and molecular dynamics simulations. Within the complex, VP35 is shown on the left and Ubiquitin on the right. The K48 and K63 Ub residues are shown in cyan on the bottom left and C-terminal on the right within Ub. B) One of the strongest interactions contributing to the stability of the complex is ARG225-GLU18. C) Mutation of ARG225 to GLU affects interactions.