Fig. 3. Nb-Ft-TRPV1^Ca2+ in D2 iSPNs stimulated with high DMF and low DMF treatment produce freezing of gait.

A. Schema for low direct magnetic field (DMF) titration. B. Magnetic field strength and individual activity heatmap example of motor activity during bilateral striatal Low DMF titration in Nb-Ft-TRPV1^Ca2+ expressing mice. Freezing of gait in different magnetic field gradients in the Low DMF titration ranges (blue bars, n=5) in Nb-Ft-TRPV1^Ca2+ expressing mice. C. Protocol and schema for High DMF and Low DMF stimulation in A2a-Cre mice injected with the double-floxed Cre-dependent AAV vector expressing the Nb-Ft-TRPV1^Ca2+ or mCherry under the control of the JET promoter. Representative tracking data of change of location in D. Nb-Ft-TRPV1^Ca2+ and E. mCherry A2a-Cre mice during High DMF (red line), Low DMF (blue line), and No DMF (green line) treatment. Effect of High DMF and Low DMF stimulation on F. Ambulation and G. Freezing of gait in Nb-Ft-TRPV1^Ca2+ (red dot/bars, n= 8) and mCherry (blue dots/bars, n=5). Error bars show SEM. * represents p value < 0.05, ** represents p value < 0.01, **** represents p value < 0.0001 with two-tailed, unpaired t-test with Welch’s correction .