Table 2. Antimicrobial susceptibility of OXA-244-producing Escherichia coli ST38 outbreak isolates in the Western region of Norway, 2020 (n = 12).
| Isolate ID | Minimum inhibitory concentration (MIC, mg/L)a,b | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TEM | PIT | CTA | CTZ | CTV | CTT | CEP | CEFa | AZT | ERT | IMI | MEM | MEV | AMI | GEN | TOB | CIP | COL | TIG | TRS | NIT | |
| KresCPE0297 | 32 | 64 | > 16 | 4 | 0.12 | 2 | 4 | 22 | 8 | 1 | 0.25 | 0.25 | 0.12 | < 1 | < 0.25 | < 0.5 | < 0.015 | 1 | 0.25 | > 16 | 32 |
| KresCPE0296 | 64 | > 64 | > 16 | 8 | 0.12 | 4 | 4 | 24 | 8 | 2 | 0.25 | 0.25 | 0.25 | < 1 | < 0.25 | < 0.5 | < 0.015 | 1 | < 0.12 | > 16 | 32 |
| KresCPE0301 | 128 | > 64 | > 16 | 8 | 0.12 | 8 | 8 | 23 | 16 | 2 | 0.25 | 0.5 | 0.25 | < 1 | < 0.25 | < 0.5 | < 0.015 | 1 | < 0.12 | > 16 | 32 |
| KresCPE0304 | 128 | > 64 | > 16 | 8 | 0.12 | 8 | 8 | 23 | 8 | 4 | 0.5 | 1 | 0.5 | < 1 | < 0.25 | < 0.5 | < 0.015 | 1 | < 0.12 | > 16 | < 16 |
| KresCPE0306 | 32 | 64 | > 16 | 4 | 0.12 | 2 | 8 | 24 | 8 | 1 | 0.25 | 0.25 | 0.12 | < 1 | < 0.25 | < 0.5 | < 0.015 | 1 | < 0.12 | > 16 | 32 |
| KresCPE0307 | 128 | > 64 | > 16 | 4 | 0.12 | 8 | 8 | 25 | 16 | 4 | 0.5 | 0.5 | 0.5 | < 1 | 0.5 | < 0.5 | < 0.015 | 1 | < 0.12 | > 16 | < 16 |
| KresCPE0308 | 128 | > 64 | > 16 | 4 | 0.12 | 8 | 8 | 22 | 8 | 4 | 0.5 | 0.5 | 0.5 | < 1 | < 0.25 | < 0.5 | < 0.015 | 1 | < 0.12 | > 16 | 32 |
| KresCPE0310 | 32 | 64 | > 16 | 4 | < 0.03 | 1 | 4 | 25 | 8 | 1 | 0.12 | 0.25 | 0.25 | < 1 | < 0.25 | < 0.5 | < 0.015 | 0.5 | < 0.12 | > 16 | < 16 |
| KresCPE0313 | 32 | 64 | > 16 | 2 | < 0.03 | 2 | 2 | 27 | 4 | 2 | 0.12 | 0.5 | 0.12 | < 1 | < 0.25 | < 0.5 | < 0.015 | 1 | 0.25 | > 16 | < 16 |
| KresCPE0314 | 128 | > 64 | > 16 | 4 | 0.12 | 4 | 8 | 22 | 8 | 4 | 1 | 1 | 0.5 | < 1 | < 0.25 | < 0.5 | < 0.015 | 1 | < 0.12 | > 16 | 32 |
| KresCPE0316 | 32 | 64 | > 16 | 4 | 0.12 | 2 | 8 | 23 | 16 | 1 | 0.25 | 0.25 | 0.12 | < 1 | < 0.25 | < 0.5 | < 0.015 | 0.5 | 0.25 | > 16 | 32 |
| KresCPE0326 | 32 | > 64 | > 16 | 4 | 0.12 | 2 | 4 | 22 | 8 | 1 | 0.25 | 0.25 | 0.5 | < 1 | 0.5 | < 0.5 | < 0.015 | 1 | < 0.12 | > 16 | 32 |
ID: identifier; MIC: minimum inhibitory concentration; OXA: oxacillinase; ST: sequence type.
a MIC data generated by broth microdilution, except for CEF where millimetre zone diameters from disc diffusion are presented.
b AMI: amikacin; AZT: aztreonam; CTA: cefotaxime; CEF: cefiderocol; CEP: cefepime; CIP: ciprofloxacin; COL: colistin; CTV: ceftazidime–avibactam; CTT: ceftolozane–tazobactam; CTZ: ceftazidime; ERT: ertapenem; GEN: gentamicin; IMI: imipenem; MEM: meropenem; MEV: meropenem–vaborbactam; NIT: nitrofurantoin; PIT: piperacillin–tazobactam; TEM: temocillin; TIG: tigecycline; TOB: tobramycin; TRS: trimethoprim–sulfamethoxazole.