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[Preprint]. 2023 Jul 18:2023.07.16.549116. [Version 1] doi: 10.1101/2023.07.16.549116

Figure 1. Cell-cell Interactions in homeostatic and regenerative liver.

Figure 1

(A-B) Venn diagram of the number of paracrine and autocrine interactions in normal and partial hepatectomy (PHx) among all 10 cell types (A) and hepatocytes only (B). (A) There are 19,528 unique interactions in normal liver and 23,640 in PHx. The normal and PHx states had 39,630 shared common interactions. (B) In hepatocytes, there were 1,632 unique interactions in normal and 1,671 after PHx, with 3,342 shared common interactions.

(C-D) Schematic top 10 CCInx weighed interactions in normal (C) and PHx (D) livers by Cytoscape network visualization. The interactions are ranked by the edge weights calculated by CCInx. PHx: 24 hr after 70% partial hepatectomy. HC: hepatocyte. NPD: non-progenitor duct cells. EC: Endothelial cells. LSEC: liver sinusoidal endothelial cells. Blood: blood lineage cells. Thy1: Thy1+ cells. KC: Kupffer cell. HSC: Hepatic Stellate cell. BEC: biliary epithelial cell. cBEC: clonal biliary epithelial cell. Arrows indicate either autocrine (from one cell to itself) or paracrine (from one cell to another) interactions.