Ext Data Fig 3: Model stability.

Depiction of the evolution of CSF stages in BioFINDER-2 (n=220, A-B) and Knight-ADRC participants (n=51, C-D) with longitudinal CSF available. As longitudinal CSF Aβ42/40 levels were not available for any BioFINDER-2 participant, we imputed this data with their baseline levels. We show the number of progressors, regressors and stable participants in A and C, for each cohort respectively. In B and D, we further show the CSF stages at follow-up. For those Knight-ADRC with more than one longitudinal visit we took the one more distant from the baseline. Abbreviations: Aβ, amyloid-β; CSF, cerebrospinal fluid.