Table 2.

Definitions of MAxO Annotation Relations

Relation	Definition
treats	The medical action can be used to treat the phenotypic feature indicated by the HPO term in persons with the indicated disease
prevents	The medical action can be used to prevent the phenotypic feature indicated by the HPO term in persons with the indicated disease
investigates	The medical action can be used to investigate the phenotypic feature indicated by the HPO term in persons with the indicated disease
contraindicated	The medical action should not be undertaken without consideration of the particular risk of harm to persons with the indicated disease
lack of observed response	The medical action was applied to persons with the indicated disease without a positive or negative response being observed