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. Author manuscript; available in PMC: 2023 Jul 26.
Published in final edited form as: Cancer Lett. 2021 Mar 15;507:112–123. doi: 10.1016/j.canlet.2021.03.006

Figure 3: Regulators and downstream targets of the Hippo pathway:

Figure 3:

The figure shows upstream activators and inhibitors of the Mammalian Hippo pathway, their binding partners and downstream target genes. Apical polarity complex (Crumbs complex) and basal polarity complex (Scribble complex) as well as cell adhesion molecules such as E-cadherin and signaling molecules positively regulate Hippo pathway (Left side of the figure), whereas, PAR complex and various signaling molecules negatively regulate Hippo pathway (Right side of the figure). These upstream regulators regulate nuclear translocation and binding of YAP/TAZ with different transcription factors that induce expression of genes involved in cell proliferation and migration, stemness, differentiation, apoptosis, DNA damages response etc.