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. 2023 Jul 26;9(30):eadf6210. doi: 10.1126/sciadv.adf6210

Table 1. Relationship between phospho-DICER1 (A), phospho-ERK (B), and clinicopathological features in LUADs.

LVI, lymph node invasion. There are a total of 88 samples in phospho-DICER1 staining and 87 samples in phospho-ERK staining. Sex data are missing from two cases; grade and LVI data are missing from six cases, and stage is missing from twelve cases. T4 only has one sample.

A. Clinicopathology factors Nuclear phospho-DICER1 expression
Negative Low Moderate High
N N N> N P*
Sex
Female 0 19 22 5 0.6046
Male 0 17 21 2
Tumor size (T)
T1 0 9 13 4 0.5589
T2 0 19 19 2
T3–T4 0 6 9 1
Stage
I 0 21 20 4 0.839
II 0 8 11 2
III 0 5 5 0
LVI
Present 0 8 12 2 0.7012
Absent 0 28 27 5
KRAS mutations
Mutated 0 9 25 4 0.0098
Not Mutated 0 28 19 3
B. Clinicopathology factors Phospho-ERK expression
Negative Low Moderate High
N N N N P*
Sex
Female 15 22 5 3
Male 8 28 2 2
Tumor size (T)
T1 6 13 3 4 0.1888
T2 10 27 1 1
T3–T4 5 9 2 0
Stage
I 12 29 0 3 0.676
II 5 14 1 1
III 4 6 0 0
LVI
Present 5 13 3 2 0.1048
Absent 16 38 2 2
KRAS mutations
Mutated 7 20 6 5 0.0034
Not mutated 16 32 1 0

*Chi-square test.