KEY RESOURCES TABLE
| Antibodies | ||
| Tau-5 | Abcam | ab80579 |
| AT8 | Thermo Scientific | MN1020 |
| PHF1 | Dr. Peter Davies | N/A |
| β-actin | Cell Signaling | 4967S |
| Tubulin | Abcam | ab4074 |
| MAP2 | Abcam | ab5392 |
| p-GR | Cell Signaling | 4161S |
| Anti-Tau, 15-25(Tau-13) | BioLegend | 835201 |
| Chemicals | ||
| NaClO3 | Sigma | 403016 |
| methyl-β-cyclodextrin | Sigma | C4555 |
| dexamethasone | Sigma | D2915 |
| mifepristone | Selleckchem | S2606 |
| TDZD-8 | Sigma | T8325 |
| TTX | Sigma | 554412 |
| EGCG | Sigma | E4143 |
| 2-deoxyglucose | Sigma | D8375 |
| Critical Assays | ||
| Total Tau Mouse ELISA Kit | Thermo Scientific | KMB7011 |
| Tau (Phospho) pS199 Mouse ELISA Kit | Thermo Scientific | KMB7041 |
| LDH Activity Assay Kit | Thermo Scientific | C20300 |
| ATP Assay Kit | Abcam | Ab83355 |
| ExoView R100 (Leprechaun) | Unchained Labs | |
| Experimental Models: mice | ||
| C57BL/6 | National Institute on Aging (NIA) | N/A |
| PS19 | The Jackson Laboratory | #008169 |
| Recombinant DNA | ||
| AAV.CAG.eGFP.P2A.hTau(P301L).WPRE.Rbg | Addgene | #140425 |
| Software | ||
| Fiji/ImageJ | NIH | https://imagej.nih.gov/ij/ |
| GraphPad Prism version 9 | GraphPad Software | https://www.graphpad.com/scientific-software/prism/ |
| ExoView R100 system | Unchained Labs | V-R1001000100064 |