Table 2 |.

Overview of pleiotropic loci and genes linked to psychiatric or neurological diseases at the genome-wide significant level

	Loci		Genes
Psychiatric disorders	Count	Fraction (%)	Count	Fraction (%)
Total	441		796
Pleiotropic with
Psychiatric disorders	60	13.6%	148	18.6%
Neurological diseases	41	9.3%	51	6.4%
Cognitive ability	64	14.5%	136	17.1%
Cortical thickness and surface area	16	3.6%	23	2.9%
Somatic disorders	46	10.4%	72	9.0%
Height	162	36.7%	463	58.2%
Neurological diseases
Total	227		497
Pleiotropic with
Psychiatric disorders	41	18.1%	51	10.3%
Neurological diseases	16	7.0%	16	3.2%
Cognitive ability	19	8.4%	35	7.0%
Cortical thickness and surface area	10	4.4%	19	3.8%
Somatic disorders	53	23.3%	58	11.7%
Height	109	48.0%	256	51.5%

Count and fraction of pleiotropic genome-wide significant loci and genes linked to psychiatric and neurological disorders across the phenotype categories. After identifying genome-wide significant loci, physically overlapping loci were merged into grouped loci. Protein-coding genes were identified using MAGMA⁷³. Across all phenotypes, 1,988 grouped loci and 7,829 genes were identified. The extended MHC-region (chr6: 25–37 Mb) was excluded from these analyses. Supplementary Tables 2–3 present the number of overlapping loci and genes for each pair of phenotypes.