Table 3 |.

Summary of tissue and cell type specificity analyses

	Tissue specific associations	Human brain cell type associations
Neurological diseases
ALZ	Upregulated in the spleen, terminal ileum of the small intestine and whole blood	Microglia
GGE	-	GABAergic and excitatory neurons
MS	Upregulated in EBV-transformed lymphocytes, the spleen, whole blood and the terminal ileum of the small intestine	Microglia and endothelial cells
PD	Upregulated in the substantia nigra	-
Psychiatric disorders
ADHD	Upregulated in the cerebral cortex	GABAergic and excitatory neurons
AN	Downregulated in the putamen and hippocampus	-
BD	-	GABAergic and excitatory neurons
MDD	Upregulated in multiple brain tissues	GABAergic neurons and oligodendrocyte progenitor cells
SCZ	Upregulated in multiple brain tissues	GABAergic and excitatory neurons
Comparators
COG	Upregulated in multiple brain tissues Downregulated in the renal cortex	GABAergic and excitatory neurons
CAD	-	Vascular cells
CRT-SA	-	Oligodendrocytes, astrocytes, stem cells, and microglia
CRT-TH	Upregulated in the cerebellar hemisphere	-
IBD	Upregulated in the spleen and whole blood Downregulated in multiple central nervous tissues	Microglia and endothelial cells
Height	Up- and downregulated in multiple tissues body-wide	Vascular cells, endothelial cells, astrocytes, oligodendrocytes, and microglia
T2D	Downregulated in multiple central nervous tissues	Vascular cells, endothelial cells, astrocytes, oligodendrocytes, and microglia

Summary of tissue and cell type specific analyses using FUMA^72,77, only significant associations after Bonferroni correction are described. Tissue analysis was based on GTEx data⁷⁶, while cell type analysis was based on 24 single-cell RNA sequencing data sets from the developing and adult human brain⁷⁷. For full results, see Supplementary Results, Supplementary Figures 4–5, Supplementary Tables 8–9.