Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

[Preprint]. 2024 Jan 30:2023.07.18.23292828. Originally published 2023 Jul 23. [Version 2] doi: 10.1101/2023.07.18.23292828

PMC10371112.1; 2023 Jul 23
PMC10371112.2; 2024 Jan 30

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.

PMC Copyright notice

Figure 6. — BKMR (Bayesian kernel machine regression) univariate dose-response associations of metal mixture components with medial temporal DTI and neuropsychological scores with 95% confidence interval band in exposed subjects; a-1) estimate of metal exposure dose-response function (y-axis) vs. log-transformed blood Mn (x-axis) for entorhinal MD; a-2) log-transformed whole blood metals at different quantiles (y-axis) vs. estimate of metal exposure dose-response function (x-axis) for entorhinal MD; b-1) estimate of metal exposure dose-response function (y-axis) vs. log-transformed blood Mn (x-axis) for entorhinal AD; b-2) log-transformed whole blood metals at different quantiles (y-axis) vs. estimate of metal exposure dose-response function (x-axis) for entorhinal AD; c-1) estimate of metal exposure dose-response function (y-axis) vs. log-transformed blood Mn (x-axis) for entorhinal RD; c-2) log-transformed whole blood metals at different quantiles (y-axis) vs. estimate of metal exposure dose-response function (x-axis) for entorhinal RD; d-1) estimate of dose-response function (y-axis) vs. log-transformed blood Fe (x-axis) for List Learning scores; d-2) log-transformed whole blood metals at different quantiles (y-axis) vs. estimate of metal exposure dose-response function (x-axis) for List Learning scores; e-1) estimate of metal exposure dose-response function (y-axis) vs. log-transformed blood Cu (x-axis) for Delayed Story Recall scores; e-2) log-transformed whole blood metals at different quantiles (y-axis) vs. estimate of metal exposure dose-response function (x-axis) for Delayed Story Recall scores. Age and education level were used as covariates. Other blood metal levels than the metal of interest in the analysis were fixed at the median on the y-axis.

Figure 6. — BKMR (Bayesian kernel machine regression) univariate dose-response associations of metal mixture components with medial temporal DTI and neuropsychological scores with 95% confidence interval band in exposed subjects; a-1) estimate of metal exposure dose-response function (y-axis) vs. log-transformed blood Mn (x-axis) for entorhinal MD; a-2) log-transformed whole blood metals at different quantiles (y-axis) vs. estimate of metal exposure dose-response function (x-axis) for entorhinal MD; b-1) estimate of metal exposure dose-response function (y-axis) vs. log-transformed blood Mn (x-axis) for entorhinal AD; b-2) log-transformed whole blood metals at different quantiles (y-axis) vs. estimate of metal exposure dose-response function (x-axis) for entorhinal AD; c-1) estimate of metal exposure dose-response function (y-axis) vs. log-transformed blood Mn (x-axis) for entorhinal RD; c-2) log-transformed whole blood metals at different quantiles (y-axis) vs. estimate of metal exposure dose-response function (x-axis) for entorhinal RD; d-1) estimate of dose-response function (y-axis) vs. log-transformed blood Fe (x-axis) for List Learning scores; d-2) log-transformed whole blood metals at different quantiles (y-axis) vs. estimate of metal exposure dose-response function (x-axis) for List Learning scores; e-1) estimate of metal exposure dose-response function (y-axis) vs. log-transformed blood Cu (x-axis) for Delayed Story Recall scores; e-2) log-transformed whole blood metals at different quantiles (y-axis) vs. estimate of metal exposure dose-response function (x-axis) for Delayed Story Recall scores. Age and education level were used as covariates. Other blood metal levels than the metal of interest in the analysis were fixed at the median on the y-axis.