Table 2.
ELS_events Effect and Severe AUD - BMI Group Differences in the Seed-to-Voxel Analysis
| Seed | Connectivity Cluster | Adjusted Estimate (β), (95% CI), p value | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Label | Lat. | Label | Lat. | x | y | z | k | P (peak, FWE) | Connectivity differences between AUD – BMI groups (AUD Low BMI vs. AUD High BMI) |
| Salience Network_SMG | L | Lateral Occipital Cortex |
R | +52 | −66 | +40 | 2584 | <0.001 | −0.06, (−0.12, −0.002), 0.03* |
| Cerebellum Crus 2 | R | +46 | −68 | −44 | −0.037, (−0.08, 0.015), 0.17 | ||||
| Cerebellum Crus 1 | R | +48 | −74 | −20 | −0.016, (−0.05, 0.019), 0.36 | ||||
| Intracalcarine cortex |
L | −08 | −76 | +12 | −0.022, (−0.06, 0.02), 0.31 | ||||
| Precuneus | +14 | −74 | +40 | 145 | 0.01 | −0.039, (−0.07, −0.005), 0.01* | |||
| Frontal Pole | L | −26 | +40 | −16 | 89 | <0.001 | −0.01, (−0.05, 0.029), 0.59 | ||
| Posterior Cingulate Gyrus |
−02 | −52 | +18 | 61 | 0.003 | −0.05, (−0.114, −0.002), 0.03* | |||
| R | Frontal Medial Cortex |
−02 | +32 | −24 | 726 | 0.02 | −0.033, (−0.07, 0.007), 0.105 | ||
| Insular Cortex | L | −52 | −32 | +22 | 8616 | <0.001 | 0.002, (−0.02, 0.02), 0.18 | ||
| Postcentral Gyrus |
L | −56 | +20 | +26 | 1011 | <0.001 | 0.04, (0.005, 0.089), 0.02* | ||
| Middle Frontal Gyrus | L | ||||||||
| Lateral Occipital Cortex |
L | −52 | −70 | +32 | 539 | <0.001 | 0.01, (−0.03, 0.06), 0.62 | ||
| Posterior Middle Temporal Gyrus |
L | −66 | −44 | +08 | 362 | <0.001 | 0.015, (−0.02, 0.05), 0.43 | ||
| Cerebellum8 | R | +36 | −48 | −54 | 206 | <0.01 | 0.004, (−0.02, 0.03), 0.77 | ||
| Cerebellum Crus2 |
R | +52 | −50 | −42 | 45 | <0.001 | 0.008, (−0.02, 0.04), 0.65 | ||
| Salience Network_ACC |
Anterior Temporal Fusiform Cortex |
L | −36 | −04 | −42 | 143 | 0.004 | −0.008, (−0.04, 0.02), 0.63 | |
| Salience Network_AIns |
L | Lateral Occipital Cortex |
R | +46 | −78 | −20 | 119 | <0.01 | 0.011, (−0.03, 0.06), 0.64 |
| Cerebellum Crusl |
R | +54 | −58 | −28 | 74 | 0.03 | 0.016, (−0.03, 0.06), 0.51 | ||
| R | Lateral Occipital Cortex |
L | −50 | −70 | +32 | 230 | <0.001 | 0.007, (−0.039, 0.054), 0.75 | |
| Hippocampus | R | +32 | −22 | −20 | 41 | 0.023 | −0.001, (−0.042, 0.039), 0.94 | ||
Notes: Statistics and descriptives for seed-to-voxel connectivity analyses. Abbreviations as follows: k: number of voxels in the cluster; Lat. (R/L): Laterality of brain region (Right/Left); FDR: false discovery rate correction; SD: standard deviation; SMG = Supramarginal Gyrus; AG = Angular Gyrus; ACC = Anterior Cingulate Cortex; AIns = Anterior Insula; AUD: Alcohol Use Disorder; BMI: Body-Mass Index. Group differences were adjusted for age, smoking status.