Extended Data Figure 5. EcDNA co-inheritance dynamics using an alternative model of ecDNA evolution.

(a) A schematic illustrating an alternative model of ecDNA evolution, paramterized by selection acting on cells carrying no, both, or either ecDNA as well as a co-segregation parameter $\gamma$. (b-c) Frequency of cells carrying both ecDNA species reported as a function of number of cells during a simulation for variable levels of co-segregation and with (b) or without (c) co-selection. (d-e) Average frequencies of cells carrying both ecDNA species (d) and the Pearson’s correlation of ecDNA copy numbers across 500 replicates of simulations of 10,000 cells while varying co-selection and co-segregation values.