Table 3. Direct HIF modulator in 2-OG-dependent dioxygenases.
| Gene symbol | Protein name | Type of reaction | Hydroxylation sites in HIFα | Non-HIF substrate examples |
|---|---|---|---|---|
| EGLN1 | PHD2 | Prolyl hydroxylation | HIF1α Pro402, Pro564; HIF2α Pro405, Pro531; HIF3α Pro492 |
FLNA, Akt |
| EGLN2 | PHD1 | Prolyl hydroxylation | HIF1α Pro402, Pro564; HIF2α Pro405, Pro531; HIF3α Pro492 |
FOXO3, Cep192, TP53 |
| EGLN3 | PHD3 | Prolyl hydroxylation | HIF1α Pro564; HIF2α Pro405, Pro531; HIF3α Pro492 |
ATF-4, ADRB2, TP53 |
| HIF1AN | FIH1 | Asparaginyl hydroxylation | HIF1α Asn803, HIF2α Asn847 |
IκBα, Notch, OTUB1, RIPK4 |