Table 6. O₂-dependent enzymes encoded by genes associated with positive selection in different high-altitude populations.

Population	Genes*
Tibetan	EGLN1 (Lorenzo et al., 2014; Bigham et al., 2010; Yi et al., 2010; Simonson et al., 2010; Xu et al., 2011; Yang et al., 2017; Peng et al., 2011; Wuren et al., 2014), CYP2E1 (Simonson et al., 2010), HMOX2 (Simonson et al., 2010; Peng et al., 2011; Wuren et al., 2014), CYP17A1 (Simonson et al., 2010; Wuren et al., 2014), SCD (Simonson et al., 2010), HIF1AN (Simonson et al., 2010), SC5D (Simonson et al., 2010), KDM5A (Simonson et al., 2010), HPD (Simonson et al., 2010), DOHH (Simonson et al., 2010), XDH (Simonson et al., 2010), CYP20A1 (Simonson et al., 2010), TMEM189 (Simonson et al., 2010), KDM4A (Simonson et al., 2010), PAOX (Simonson et al., 2010)
Andean	EGLN1 (Bigham et al., 2010; Bigham et al., 2009), EGLN2 (Bigham et al., 2009), NOS1 (Bigham et al., 2009), NOS2 (Bigham et al., 2010; Bigham et al., 2009; Crawford et al., 2017), DUOX2 (Jacovas et al., 2018), CYP39A1 (Eichstaedt et al., 2014), KDM2A (Eichstaedt et al., 2014), KMO (Eichstaedt et al., 2014), PLOD3 (Eichstaedt et al., 2014), P3H3 (Eichstaedt et al., 2014), CPOX (Eichstaedt et al., 2014), CYP24A1 (Eichstaedt et al., 2014)
Ethiopian	PCYOX1 (Scheinfeldt et al., 2012)

^*Known hypoxia sensors are highlighted in red.