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. 2023 Jun 22;8(12):e170307. doi: 10.1172/jci.insight.170307

Figure 1. Metabolic response to ingesting 75 grams of glucose before and after weight maintenance or progressive weight loss induced by a low-calorie diet in people with obesity without type 2 diabetes.

Figure 1

(A–C and E–G) Plasma glucose (A and E) and insulin (B and F) concentrations, and insulin secretion rate (C and G) before and after ingesting 75 grams of glucose. (D and H) The relationship between insulin secretion rate and plasma glucose concentration during the early postprandial period (first 30 min) after glucose ingestion when plasma glucose was rapidly rising before and after weight maintenance (left, A–D) and before and after progressive 6%, 11%, and 16% weight loss induced by a low-calorie diet (right, E–H). Data are expressed as mean ± SEM. OB-PWL, n = 9; OB-WM, n = 14. ISR, insulin secretion rate; OB, obese; PWL, progressive weight loss; WM, weight maintenance.