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. 2023 Jun 22;8(12):e170307. doi: 10.1172/jci.insight.170307

Figure 2. Metabolic response to ingesting a mixed meal containing ~50 g of glucose before and after marked (~20%) weight loss induced by a low-calorie diet alone or laparoscopic gastric banding or Roux-en-Y gastric bypass surgery.

Figure 2

(A–D) Basal and postprandial plasma glucose (A) and insulin (B) concentrations, insulin secretion rate (C), and the relationship between insulin secretion rate and plasma glucose concentration during the early postprandial period (first 45 min after initiating liquid mixed meal ingestion) when plasma glucose was rapidly rising (D) before and after weight loss induced by Roux-en-Y gastric bypass surgery or laparoscopic gastric banding. (E–H) Basal and postprandial plasma glucose (E) and insulin (F) concentrations, insulin secretion rate (G), and the relationship between insulin secretion rate and plasma glucose concentration during the early postprandial period (first 50 min after initiating liquid mixed meal ingestion) when plasma glucose was rapidly rising (H) before and after weight loss induced by Roux-en-Y gastric bypass surgery or a low-calorie diet alone in people with obesity and type 2 diabetes. ISR, insulin secretion rate; LAGB, laparoscopic adjustable gastric banding; LCD, low-calorie diet; OB, obese; RYGB, Roux-en-Y gastric bypass; T2D, type 2 diabetes. Data are expressed as mean ± SEM. OB-LAGB, n = 11; OB-RYGB, n = 12; T2D-LCD, n = 10; T2D-RYGB, n = 9.