Figure 2.

Manhattan plots generated from genome-wide association study analysis of the AKI cases and controls. Plots include (A) association results for imputed single-nucleotide polymorphisms (variants) with AKI in the discovery cohort. (B) Genomic locus for the DISP1-TLR5 top hits, rs17538288 and rs7546189 at higher magnification. LD, r², is indicated relative to the variant with lowest P value (purple marker) by colored scale. Notice that the top two DISP1-TLR5 hits are not in LD with each other (r²=0.24). Genes located near each locus are displayed in the bottom panels. DISP1, dispatched resistance-nodulation-division (RND) transporter family member 1; LD, linkage disequilibrium; TLR5, toll-like receptor 5.