Table 2.
Summary of suggestive imputed variant associations with AKI in Assessment, Serial Evaluation, and Subsequent Sequelae of AKI for joint all ancestry and stratified to European American analysis
| Variant | Chr | Position | Gene | MA | MAF | EA MAF | Genotyped | Imputation Quality (r2) | All Ancestry OR (95% CI) | All Ancestry Pa |
EA OR (95% CI) |
EA Pa |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs17538288 | 1 | 223192017 | DISP1-TLR5 | A | 0.439 | 0.429 | Imputed | 0.97 | 1.54 (1.31 to 1.81) | 1.47E-07 | 1.50 (1.25 to 1.79) | 8.49E-06 |
| rs7546189 | 1 | 223224864 | DISP1-TLR5 | T | 0.347 | 0.349 | Imputed | 0.96 | 1.54 (1.3 to 1.82) | 4.85E-07 | 1.62 (1.35 to 1.96) | 3.39E-07 |
| rs80052123 | 1 | 89493224 | GBP3 (5′) | A | 0.143 | 0.152 | Direct | 1.0 | 1.71 (1.36 to 2.15) | 3.41E-06 | 1.67 (1.31 to 2.13) | 3.95E-05 |
| rs6533107 | 4 | 104706914 | TACR3 5′ | A | 0.352 | 0.374 | Imputed | 0.97 | 0.66 (0.56 to 0.78) | 1.09E-06 | 0.65 (0.54 to 0.78) | 4.38E-06 |
| rs9998646 | 4 | 188592759 | LINC02492 | C | 0.441 | 0.447 | Imputed | 0.99 | 0.68 (0.59 to 0.80) | 1.22E-06 | 0.67 (0.56 to 0.79) | 4.10E-06 |
| rs72607731 | 7 | 124916848 | LOC101928283 | T | 0.237 | 0.259 | Imputed | 0.97 | 1.59 (1.32 to 1.92) | 1.65E-06 | 1.53 (1.25 to 1.88) | 3.12E-05 |
| rs1368999 | 9 | 28879870 | LINGO2 | C | 0.492 | 0.54 | Imputed | 0.98 | 0.67 (0.57 to 0.80) | 3.32E-06 | 0.63 (0.53 to 0.76) | 6.10E-07 |
| rs4414368 | 13 | 83974202 | Gene Desert | T | 0.178 | 0.123 | Imputed | 0.99 | 0.58 (0.46 to 0.72) | 1.64E-06 | 0.62 (0.47 to 0.82) | 0.0006643 |
| rs9945894 | 18 | 9083721 | NDUFV2 5′ | C | 0.077 | 0.075 | Imputed | 0.98 | 2.03 (1.50 to 2.75) | 4.83E-06 | 1.90 (1.36 to 2.65) | 0.000163 |
variant, single-nucleotide polymorphism; Chr, chromosome; MA, minor allele; MAF, minor allele frequency; EA, European American; OR, odds ratio; CI, confidence interval; DISP1, dispatched resistance-nodulation-division (RND) transporter family member 1; TLR5, toll-like receptor 5.
a
P value and odds ratio after adjustment for patient's age, sex, diabetes, hypertension, enrollment site, and first ten principal components of ancestry in cases and controls.