Table 5.

Correlation matrix of protein biomarkers with change from baseline in expression of key transcripts

Gene	Protein
	CRP		fCLP		IL-17A		IL-22
	P	Rho	P	Rho	P	Rho	P	Rho
S100A8	0.012	0.345	<0.001	0.515	<0.001	0.505	0.120	0.235
S100A9	0.008	0.362	<0.001	0.494	<0.001	0.534	0.044	0.301
IL1β	0.004	0.389	0.009	0.377	<0.001	0.545	0.033	0.319
IL6	0.016	0.332	0.005	0.399	<0.001	0.499	0.059	0.283

Pearson correlation of change from baseline in gene expression with log2 (protein) levels from the residuals of the linear mixed-effects models that each adjusts for batch, age, and sex.

CRP, C-reactive protein; fCLP, fecal calprotectin; IL, interleukin.