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. 2023 Jul 10;8(13):e160416. doi: 10.1172/jci.insight.160416

Figure 5. Cardiac fibrotic effects of Ang II (infused via osmotic minipumps for 2 weeks) in control and Fibro GC-B–KO male and female mice.

Figure 5

Left panels: Data from males; right panels: data from females. (A) The collagen areas were determined as fraction (%) of the total area of the corresponding Sirius red–stained LV section. n = 7 sham and 7 Ang II–treated males and 5 sham and 7 Ang II–treated females per genotype. (B) qRT-PCR analyses of LV mRNA expression of connective tissue growth factor (CTGF) and periostin. Values are the ratios of mRNA levels relative to S12, expressed as x-fold vs. sham mice. Studies were performed with 2 LV samples from each mouse. n = 8 samples from sham control, 8 from sham KO, and 12 from Ang II–treated male mice per genotype. n = 10 samples from sham and 14 from Ang II–treated female mice per genotype. *P < 0.05 vs. sham; #P < 0.05 vs. control mice (2-way ANOVA followed by Tukey’s multiple-comparison test).