Figure 2. Male and female Rbm20^ΔRS mice develop a DCM-like phenotype.

(A–H) Graphs showing LVID;s (A), LVID;d (B), ESV (C), EDV (D), SV (E), EF (F), FS (G), and CO (H) as determined by M-mode echocardiography in 4-month-old male WT (n = 8) and Rbm20^ΔRS (n = 7) mice, as well as female WT (n = 7) and Rbm20^ΔRS (n = 11) mice. Data are shown as mean ± SD. Dots represent measurements from individual animals. Two-way ANOVA with the Šídák method for multiple comparisons was performed to analyze the effect of sex and genotype on each of the aforementioned parameters. The interaction between sex and genotype was not significant for any parameter. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.