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. 2023 Jul 10;8(13):e167329. doi: 10.1172/jci.insight.167329

Figure 8. Proposed model.

Figure 8

Residual inflammation maintains the upregulation of TLR7 and IRF-5 in memory CD4+ T cells from ART HIV-1+ individuals but not in HIVfree individuals. The activation of the TLR7/IRF-5 axis feeds into the Fas/FasL pathway, predisposing and enhancing Fas-mediated apoptosis only in memory CD4+ T cells from ART HIV-1+ individuals. Finally, we proposed that this mechanism can be blocked by adding IRF-5 inhibitory peptides, which block the predisposition to Fas-mediated cell death. Created with BioRender.com.