TABLE 5.

Comparison of bactericidal activity by patient and control neutrophils

Study wk	n	Median control (% kill)	Median ratio (treated/control)	Median % difference (treated/control)	Pa	Median % change from baseline	Pb
0	12	79	0.67	−25	<0.001
8	13	76	0.49	−37	<0.001	−6.4	0.35
20	12	78	0.76	−18	<0.001	6.2	0.63
32	8	71	0.79	−14	<0.004	0	0.24

^aAt each time point, patients exhibited lower values than healthy controls. The P values are binomial probabilities assessing the probability that this could have happened by chance. 

^bTreated subjects versus subjects at week 0. The P values were calculated with Wilcoxon matched-pairs tests assessing the statistical significances of a change from the baseline.