FIG. 4.

Inhibition by CI-959-A of MHC, costimulatory molecule, and adhesion molecule expression on CD4⁺ T cells. PBMCs were stimulated with PHA (2 μg/ml) for 7 days in the presence of CI-959-A (1 μM) or CI-959 (1 μM). The activated CD4⁺ T cells were gated and examined for expression of CD54, CD58, CD86, HLA-DR, and CD28. ----, control MAb; ———, the indicated MAb. The number above each histogram represents the mean fluorescence intensity. Data represent those from more than three separate experiments.