Table 2.

The incidence rates of the non-synonymous single nucleotide polymorphisms (nsSNPs) in the ABC efflux pumps among strains with higher (High) and lower (Low) MIC values.^a

Name of the protein	ATP-binding cassette domain-containing protein				ABC transporter ATP-binding protein		ATP-binding cassette domain-containing protein		ABC transporter permease subunit		ABC transporter permease subunit		ATP-binding cassette domain-containing protein
Accessibility	WP_146368471.1				WP_146368786.1		WP_226364443.1		WP_146368361.1		WP_146368222.1		QDY87225.1
nsSNP location	250		1,339		1,069		1,494		925		704		667
	High	Low	High	Low	High	Low	High	Low	High	Low	High	Low	High	Low
Enrofloxacin	33.3% (8/24)	6.3% (1/16)	41.6% (10/24)	6.3% (1/16)	62.5% (15/24)	0.0% (0/16)	58.3% (14/24)	12.5% (2/16)	66.7% (16/24)	12.5% (2/16)	66.7% (16/24)	18.8% (3/16)	54.2% (13/24)	6.3% (1/16)
Tilmicosin	36.8% (7/19)	9.5% (2/21)	36.8% (7/19)	19.0% (4/21)	63.1% (12/19)	14.3% (3/21)	57.9% (11/19)	23.8% (5/21)	63.2% (12/19)	28.6% (6/21)	68.4% (13/19)	23.8% (5/21)	57.9% (11/19)	14.3% (3/21)
Tylosin	35.0% (7/20)	10.0% (2/20)	35.0% (7/20)	20.0% (4/20)	60.0% (12/20)	15.0% (3/20)	60.0% (12/20)	20.0% (4/20)	60.0% (12/20)	25.0% (5/20)	65.0% (13/20)	30.0% (6/20)	55.0% (11/20)	15.0% (3/20)
Tylvalosin	75.0% (3/4)	16.7% (6/36)	50.0% (2/4)	25.0% (9/36)	75.0% (3/4)	33.3% (12/36)	75.0% (3/4)	36.1% (13/36)	75.0% (3/4)	41.7% (15/36)	75.0% (3/4)	44.4% (16/36)	75.0% (3/4)	30.6% (11/36)
Lincomycin	60.0% (3/5)	17.1% (6/35)	80.0% (4/5)	20.0% (7/35)	100.0% (5/5)	28.6% (10/35)	80.0% (4/5)	34.3% (12/35)	100.0% (5/5)	37.1% (13/35)	100.0% (5/5)	40% (14/35)	80.0% (4/5)	28.6% (10/35)
Tiamulin	54.5% (6/11)	10.3% (3/29)	54.5% (6/11)	17.2% (5/29)	63.6% (7/11)	27.6% (8/29)	63.6% (7/11)	31.0% (9/29)	72.7% (8/11)	34.5% (10/29)	81.8% (9/11)	34.4% (10/29)	63.6% (7/11)	24.1% (7/29)

^aExact numbers of the strains that displayed the nsSNP out of every strain with higher and lower MIC values are shown in brackets.