TABLE 2.
Segment homologies among GWS RPAs and human chromosome 22q11.2
| RPA, sequence, and position | GenBank accession no. | 22q11.2 GenBank sequence | Segment location | No. of other 100% matches |
|---|---|---|---|---|
| 759-nt RPA | ||||
| 15mers | ||||
| 59–73 | HSU07000 | 809–823 | Between two Alu regions | 0 human, 0 nonhuman |
| 83–97 | HSCN37F10 | 36332–36346 | Between MIR and Alu | 0 human, 0 nonhuman |
| 711–725 | HS322B1 | 45987–46001 | Between AluSx and MIR | 1 human, 0 nonhuman |
| 14mers | ||||
| 11–24 | D86998 | 23151–23164 | Between V2–8 and V1–3 | 2 human, 2 nonhuman |
| 136–149 | U30597 | 227965–227978 | Between two Alu regions | 0 human, 8 nonhuman |
| 194–207 | HSE78G1 | 29369–29382 | Between two Alu regions | 0 human, 3 nonhuman |
| 343–356 | HSN44A4 | 1460–1473 | In AluY | 9 human, 25 nonhuman |
| 377–390 (GWV 1) | HSN38E12 | 19903–19916 | Between AluSx and repeat region | 2 human, 3 nonhuman |
| 377–390 (GWV 2 and 3) | HSF4G12 | 39069–39082 | Between two repeat regions | 18 human, 22 nonhuman |
| 462–475 | HSN20A6 | 17205–17218 | Near flanking repeat region | 4 human, 1 nonhuman |
| 551–564 | AC000068 | 14136–14149 | No description | 0 human, 2 nonhuman |
| 634–647 | D87021 | 17508–17521 | Between V2–7 and V2–6 light-chain genes | 15 human, 7 nonhuman |
| 414-nt RPA | ||||
| 15mers | ||||
| 190–204 | AC002475 | 1301–1315 | No description | 23 human, 1 nonhuman |
| 310–324 | HSN74G7 | 10657–10671 | Between Alu repeat and repeat region | 3 human, 0 nonhuman |
| 14mers | ||||
| 136–149 | HS65B7 | 4097–4110 | Inside MIR repeat | 4 human, 0 nonhuman |
| 155–168 | HSE78G1 | 35878–35891 | Between repeat regions | 18 human, 2 nonhuman |
| 270–283 | HSE146D10 | 522–535 | Between repeat regions | 4 human, 2 nonhuman |
| 395–408 | HSE116C6 | 9265–9278 | Between Alu and repeat region | 1 human, 14 nonhuman |
a
Sequences from a survey of consensus sequences with 100% homology to the designated RPAs from sera from GWVs with GWS (GWS RPAs) were divided into human and nonhuman categories according to the GenBank definition of the entry. MIR, mammalian-wide interspersed repeat.