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In vitro anti-tumor cytotoxicity analysis of ICAM1-ADCs
(A) Schematic illustration and chemical structures of ICAM1-ADC linkers and warheads.
(B–F) in vitro cell growth inhibitory activity in BCPAP(B), IHH4(C), 8505C(D), TCO1(E), and 293T cell (F), The cells were treated with ICAM1 antibody, I1-MMAE, I1-DXd paclitaxel and vemurafenib (in BRAF mutation cells). Each point represents the mean and SD (n = 3).
