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. 2023 Jun 6;113(2):186–194. doi: 10.1007/s00223-023-01101-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — The proportion of people using medication according to ATC main groups; comparing patients with a pathogenic or a rare suspicious variant in LRP5, PLS3, or WNT1 to the total Dutch population. Due to patient privacy, absolute numbers for certain categories cannot be shown; this is indicated by capped lines. For patients 0–24 years old, values ≤14% are not shown; for patients 45–64 years old, values ≥88% are not shown; for patients 65 years and older, values ≥79% are not shown. Y, years. For more information on ATC main groups the ATC/DDD index of the WHO Collaborating Centre for Drug Statistics Methodology can be consulted [27]. ATC, Anatomical Therapeutic Chemical; DDD, defined daily dose; WHO, World Health Organization.