Table 1.

Admission incidence rate comparing the number of hospitalizations of Dutch patients with a pathogenic or a rare suspicious variant in LRP5, PLS3 or WNT1 to the total population and OI population between 2013 and 2019

Mean yearly admission incidence rate on average per person	0–24 y	24–44 y	45–64 y	≥ 65 y	Total
LRP5, PLS3, or WNT1 cohort	0.49	0.13	0.31	0.53	0.32
Total population [28, 29]	0.10	0.12	0.20	0.44	0.20
OI population [25]	0.81	0.25	0.33	NA*	0.51
Incidence rate ratios (IRR)	0–24 y	24–44 y	45–64 y	≥ 65 y	Total
LRP5, PLS3, or WNT1 cohort  compared to the total population	4.81	1.04	1.58	1.22	1.63
LRP5, PLS3, or WNT1 cohort compared to OI population	0.60	0.52	0.94	NA*	0.62
Mean yearly admission incidence and IRRs	LRP5	PLS3	WNT1
Mean yearly admission incidence rate	0.24	0.40	0.44
IRR compared to the total Dutch population	1.24	2.05	2.23
IRR compared to Dutch OI cohort	0.47	0.78	0.85

Admissions include both day−case and inpatient admissions

IRR incidence rate ratio, NA not available, y years

* Since the Dutch OI population consisted of a relatively low number of patients 80 years and older, the ≥65 y age group could not be calculated accurately