Table 2.
Incidence ratio of the number of DTCs per person for patients with a pathogenic or a rare suspicious variant in LRP5, PLS3 or WNT1 compared to the total Dutch population during 2013–2017
| Medical specialty for which a DTC was opened: | Total | WNT1 | LRP5 | PLS3 | OI population [25] |
|---|---|---|---|---|---|
| Total | 2.01 | 2.31 | 1.82 | 2.22 | 2.63 |
| Pediatrics | 4.78 | 2.62 | 5.03 | 7.19 | 9.90 |
| Surgery | 2.38 | 2.69 | 2.06 | 3.01 | 2.88 |
| Plastic surgery | 2.04 | 3.79 | 1.85 | NA | 1.72 |
| Orthopedics | 4.37 | 4.34 | 4.49 | 3.99 | 7.38 |
| Internal medicine | 2.63 | 2.86 | 2.60 | 2.37 | 1.74 |
| Ophthalmology | 1.02 | 1.28 | 0.67 | 1.85 | 1.07 |
| Otorhinolaryngology | 1.85 | 2.43 | 1.44 | 2.41 | 2.15 |
| Urology | 1.46 | 3.03 | 0.45 | 2.56 | 0.79 |
| Obstetrics and gynecology | 1.70 | 3.14 | 1.26 | 0.99 | 1.61 |
| Gastroenterology | 0.51 | 0.64 | 0.48 | NA | 0.71 |
| Cardiology | 0.57 | 1.27 | 0.42 | NA | 0.59 |
| Pulmonology | 0.63 | 1.66 | 0.36 | NA | 2.27 |
| Neurology | 0.99 | 0.89 | 0.96 | 1.26 | 1.19 |
| Anesthesiology | 2.75 | 3.95 | 3.02 | NA | 1.60 |
| Dermatology | 0.87 | 0.64 | 1.01 | 0.76 | 0.85 |
| Rheumatology | 3.86 | 4.07 | 2.91 | 6.79 | 0.80 |
| Revalidation | 7.68 | 6.13 | 7.16 | 11.85 | 20.90 |
| Clinical genetics | 17.00 | 12.17 | 16.35 | 26.67 | 25.82 |
| Audiology center | 3.58 | 6.07 | 2.05 | 5.04 | 7.54 |
Numbers present the incidence rate ratios calculated by dividing the mean number of DTCs per person in the LRP5, PLS3, and/or WNT1 group by the mean number of DTCs per person in the total Dutch population [28, 30] If the number of DTCs was based on less than three patients, the numbers are not shown (NA).
DTC diagnosis treatment combination, NA not avaiable