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. 2023 Jul 26;14:138. doi: 10.1007/s12672-023-00733-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Photomicrograph of the colon tissue section. Figures (A and B) representing control showed a normal histological structure of the colon. However, in Figure (C and D) the DMH + IR showed hyperplasia of the mucosal glands, dysplastic changes, and inflammatory cell infiltration. Figure (E and F) colon tissues after treatment with 5-FU showed moderate dysplasia and some inflammatory cells. Furthermore, 5-FU nanogel lowered the hyperplasia and the inflammatory cells (figure G and H)