Table 4.

Multivariate Cox proportional regression analysis of prognostic factors affecting BCFI and OS, The Ruijin cohort.

Characteristics	BCFI		OS
	HR (95% CI)	P value	HR (95% CI)	P value
Age		0.160		0.019
< 40	1.00		1.00
40–49	0.66 (0.43–1.03)	0.067	0.85 (0.40–1.79)	0.661
50–70	0.66 (0.44–0.98)	0.041	0.97 (0.49–1.93)	0.933
> 70	0.82 (0.47–1.44)	0.484	2.06 (0.93–4.59)	0.076
Menstrual status				0.026
Pre/Peri-	/		1.00
Post-	/		2.38 (1.11–5.12)
CCI		0.616		0.903
0	1.00		1.00
1–2	0.88 (0.65–1.19)	0.400	0.91 (0.60–1.39)	0.668
3 +	0.83 (0.50–1.38)	0.473	0.92 (0.49–1.70)	0.783
Tumor stagea		< 0.001		< 0.001
I	1.00		1.00
II	2.07 (1.44–2.96)	< 0.001	1.90 (1.14–3.15)	0.013
III	4.35 (2.86–6.61)	< 0.001	5.95 (3.35–10.56)	< 0.001
Histological grade		0.128		0.360
I	1.00		1.00
II	8.90 (1.23–64.36)	0.030	1.26 (0.44–3.56)	0.670
III	11.21 (1.36–72.71)	0.024	1.76 (0.60–5.11)	0.302
NA	8.52 (1.06–59.70)	0.044	1.29 (0.41–4.06)	0.664
LVI		0.157		0.386
Negative	1.00		1.00
Positive	1.31 (0.90–1.89)		1.27 (0.74–2.17)
Molecular subtypeb		0.025		0.004
HR + /HER2−	1.00		1.00
HER2 +	1.22 (0.90–1.65)	0.197	1.21 (0.76–1.91)	0.424
TNBC	1.63 (1.14–2.32)	0.007	2.17 (1.36–3.45)	< 0.001
Ki67		0.046		0.039
< 14%	1.00		1.00
≥ 14%	1.44 (1.01–2.07)		1.72 (1.03–2.88)
Chemotherapy		0.971		0.110
No	1.00		1.00
Yes	1.01 (0.69–1.47)		0.66 (0.39–1.10)
Radiation therapy		0.062		0.902
No	1.00		1.00
Yes	1.05 (0.78–1.41)		0.97 (0.64–1.48)
Time to surgery		0.023		0.008
≤ 1 week	1.00		1.00
1–2 weeks	1.23 (0.75–2.02)	0.406	2.05 (1.18–3.57)	0.011
> 2 weeks	1.77 (1.03–3.04)	0.040	2.09 (1.04–4.19)	0.037

Significant values are in bold.

^aCause tumor size and ALN status are components of tumor stage, we included tumor stage as an integral factor into multivariate analysis.

^bCause ER, PR and HER2 are components of molecular subtype, we included subtype as an integral factor into multivariate analysis.