Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jun 26;113(2):246–253. doi: 10.1007/s00223-023-01099-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — Calcium, creatinine, PTHrP and PTH trends. This figure shows the patient’s calcium, creatinine, PTHrP and PTH levels from initial admission to 10 months after surgical resection. Of note, denosumab 120 mg dose was given once on hospital day 2 after IV fluids did not lead to significant decline in calcium levels. Subsequently, IV Zoledronic acid 4 mg was given on hospital day 4, and despite multiple doses of IV zoledronic acid, calcium levels remained elevated. Once methylprednisolone was initiated, calcium levels started to normalize. When glucocorticoids were tapered, there was an increase in calcium levels, but after increasing the dose of methylprednisolone back to 12 mg twice daily (24 mg total daily) for five days, and then 10 mg twice daily (20 mg daily) afterwards, the patient maintained normal calcium and PTHrP levels until surgery. Shortly after surgery, the patient developed hypocalcemia with elevated PTH levels, but continued to have low PTHrP levels. He was treated briefly with calcium supplementation for hungry bone syndrome. Subsequent follow up calcium and PTHrP levels continue to remain normal up to the time of this publication (later results not included on graph given stability of labs and to allow improved visualization of initial biochemical trends)