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. Author manuscript; available in PMC: 2025 Apr 1.
Published in final edited form as: Eur Urol. 2023 Jan 28;85(4):373–381. doi: 10.1016/j.eururo.2023.01.020

Table 3 –

Effects of short-term androgen deprivation therapy by risk group

N Cancer-
related event
(metastasis or
cancer death)		 Competing mortality Event-free survival
(Cancer-related event or
competing mortality)		 Overall survival
<10 yr ≥10 yr <10 yr ≥10 yr <10 yr ≥10 yr
All patients 1945 0.61 (0.49, 0.76) 0.90 (0.77, 1.05) 1.49 (1.21, 1.84) 0.80 (0.70, 0.92) 1.24 (1.04, 1.49) 0.82 (0.71, 0.94) 1.20 (1.02, 1.43)
Standard risk group a
 Low risk/FIR 996 0.82 (0.58, 1.15) 0.84 (0.67, 1.05) 1.65 (1.25, 2.19) 0.85 (0.70, 1.04) 1.41 (1.09, 1.81) 0.85 (0.69, 1.05) 1.37 (1.08, 1.74)
 UIR/high risk 768 0.47 (0.34, 0.64) 0.96 (0.75, 1.23) 1.22 (0.86, 1.73) 0.75 (0.61, 0.92) 0.97 (0.72, 1.29) 0.79 (0.64, 0.98) 0.94 (0.72, 1.24)
Interaction p value
 Low/FIR vs UIR/high 0.019 0.43 0.21 0.36 0.06 0.64 0.044
 All strata 0.062 0.44 0.23 0.50 0.08 0.71 0.058
Relative risk group
 Low omega score (<0.314) 996 0.81 (0.58, 1.11) 0.84 (0.69, 1.04) 1.46 (1.11, 1.93) 0.84 (0.70, 1.01) 1.33 (1.03, 1.72) 0.80 (0.66, 0.97) 1.35 (1.06, 1.71)
 High omega score (≥0.314) 949 0.52 (0.39, 0.69) 0.93 (0.73, 1.19) 1.53 (1.11, 2.09) 0.75 (0.61, 0.91) 1.15 (0.89, 1.49) 0.80 (0.65, 0.99) 1.06 (0.84, 1.35)
Interaction p value
 Low vs high 0.046 0.55 0.79 0.42 0.44 0.96 0.17
 All strata 0.057 0.87 0.78 0.23 0.42 0.74 0.13
 Continuous 0.040 0.81 0.68 0.16 0.26 0.67 0.043
Concordant vs. discordant groups a
Standard: low/FIR
Omega score: low		 710 1.02 (0.66, 1.57) 0.89 (0.70, 1.13) 1.64 (1.18, 2.29) 0.92 (0.74, 1.15) 1.49 (1.10, 2.02) 0.89 (0.71, 1.12) 1.48 (1.11, 1.97)
Standard: low/FIR
Omega score: high 		286 0.55 (0.30, 0.99) 0.57 (0.32, 1.01) 1.77 (1.03, 3.03) 0.57 (0.36, 0.90) 1.30 (0.83, 2.04) 0.60 (0.36, 1.00) 1.16 (0.76, 1.77)
Standard: UIR/high
Omega score: low		 175 0.35 (0.17, 0.74) 0.86 (0.54, 1.39) 0.84 (0.41, 1.72) 0.68 (0.44, 1.03) 0.73 (0.39, 1.33) 0.68 (0.44, 1.05) 0.81 (0.45, 1.43)
Standard: UIR/high
Omega score: high		 593 0.50 (0.36, 0.71) 0.99 (0.74, 1.32) 1.37 (0.92, 2.05) 0.77 (0.61, 0.97) 1.05 (0.75, 1.46) 0.83 (0.65, 1.06) 0.99 (0.73, 1.35)

FIR = favourable intermediate risk; UIR = unfavourable intermediate risk.

a

Note that 181 patients with missing FIR/UIR status were omitted. All p values are two sided from Cox proportional hazard models (Wald test).