Table 1. Characteristics and clinicopathological data for immunosuppressive responders and non-responders.
| Variable | Reference interval |
Respondersa | n | Non-respondersb | n | P value |
|---|---|---|---|---|---|---|
| Sex | - | Male 8 / female 10 | 18 | Male 3 / female 6 | 9 | 0.692 |
| Neutering status (intact/neutered) | - | Intact 6 / neutered12 | 18 | Intact 2 / neutered 7 | 9 | 0.676 |
| Age (years)* | - | 9 (3–14) | 18 | 12 (5–14) | 9 | 0.049 |
| Body weight (kg) | - | 6.41 (4.1–30.5) | 18 | 5.4 (3.48–7.66) | 9 | 0.198 |
| PCV (%) | 37–55 | 16.5 (8–27) | 18 | 18 (12–25) | 9 | 0.435 |
| Reticulocytes (×103/μL) | 10–110 | 19.9 (0–50.5) | 18 | 22.2 (5.5–38.9) | 9 | 0.338 |
| Platelets (×103/μL) | 148–484 | 366 (49–889) | 18 | 307 (136–843) | 9 | 0.41 |
| CR% | 0–1.0 | 0.26 (0–0.72) | 18 | 0.34 (0.06–0.85) | 9 | 0.202 |
| Result of bone marrow aspiration | ||||||
| Polychromatophils (+ / −) | - | Observed 12 / not observrd 5 | 17 | Observed 7 / not observrd 2 | 9 | 1 |
| Rubriphagocytosis (+ / −) | - | Observed 5 / not observrd 12 | 17 | Observed 3 / not observrd 6 | 9 | 1 |
| EMR* | 0.02–0.12 | 0.14 (0.06–0.50) | 17 | 0.42 (0.06–0.80) | 9 | 0.026 |
| GMR* | 0.04–0.15 | 0.05 (0.01–0.76) | 17 | 0.05 (0–0.11) | 9 | 0.046 |
| Macrophages (%) | <1 | 0.2 (0–0.8) | 17 | 0.2 (0–4.2) | 9 | 0.235 |
CR%, corrected reticulocyte %; ME ratio, myeloid-to-erythroid ratio; EMR, erythroid-maturation ratio; GMR, granulocyte-maturation ratio. Data expressed as median (range) or number. *Significant difference between immunosuppressive responders and non-responders (P<0.05). aResponders defined as absolute reticulocyte concentration increased to ≥60,000/μL; bNon-responders defined as absence of increased absolute reticulocyte concentration (<60,000/μL) up to 105 days after starting treatment.